Predictors of SIV recrudescence following antiretroviral treatment interruption
نویسندگان
چکیده
منابع مشابه
CD4+ count-guided interruption of antiretroviral treatment.
BACKGROUND Despite declines in morbidity and mortality with the use of combination antiretroviral therapy, its effectiveness is limited by adverse events, problems with adherence, and resistance of the human immunodeficiency virus (HIV). METHODS We randomly assigned persons infected with HIV who had a CD4+ cell count of more than 350 per cubic millimeter to the continuous use of antiretrovira...
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In 1991, some 90 countries or areas where 42% of the world's population resided were considered malarious and estimation of malaria mortality worldwide per year was 1.5 to 3 million'). The Ministry of Justice reported that the total number of Japanese who went abroad was as many as 11,790, 699 and the number of foreigners who entered Japan for the first time was 3,251,753 in 1992. Consequently ...
متن کاملInterruption of antiretroviral treatment in HIV-infected children
.............................................................................................................................................................. 51 ZUSAMMENFASSUNG .......................................................................................................................................... 52 ACKNOWLEDGEMENTS................................................................
متن کاملGenetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy
HIV and SIV infection dynamics are commonly investigated by measuring plasma viral loads. However, this total viral load value represents the sum of many individual infection events, which are difficult to independently track using conventional sequencing approaches. To overcome this challenge, we generated a genetically tagged virus stock (SIVmac239M) with a 34-base genetic barcode inserted be...
متن کاملEarlier initiation of antiretroviral therapy in treatment-naïve patients: implications of results of treatment interruption trials.
PURPOSE OF REVIEW To discuss the implications of the results of the Strategies for Management of Antiretroviral Therapy Study and other treatment interruption studies on the question of when antiretroviral therapy should be initiated. RECENT FINDINGS In the Strategies for Management of Antiretroviral Therapy Study, CD4 count-guided, episodic use of antiretroviral therapy as compared with cont...
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ژورنال
عنوان ژورنال: eLife
سال: 2019
ISSN: 2050-084X
DOI: 10.7554/elife.49022